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linked patient

Patient linked to coronavirus outbreak at Millinocket wedding has died – WGME

Patient linked to coronavirus outbreak at Millinocket wedding has died – WGME
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patient Reported

Patient Is Reported Free of H.I.V., but Scientists Urge Caution – The New York Times

Health|Patient Is Reported Free of H.I.V., but Scientists Urge Caution

Brazilian scientists say the man no longer shows signs of the infection after taking a powerful drug cocktail. But the preliminary results require confirmation.

Credit…Alexandre Schneider/Getty Images for amfAR

A 35-year-old man in Brazil may be the first to experience long-term remission from H.I.V. after treatment with only a specially designed cocktail of antiviral drugs, researchers said on Tuesday.

Just two people have been confirmed cured of H.I.V. so far, both after risky treatments involving bone-marrow transplants for their cancers.

The Brazilian patient, who was not identified, has not shown signs of lingering H.I.V. infection in blood tests that detect the virus, according to investigators at the Federal University of Sao Paulo, a prestigious research institution. He also does not seem to have detectable antibodies to the virus.

“Although still an isolated case, this might represent the first long-term H.I.V. remission” without a bone-marrow transplant, the scientists said. They presented the results at AIDS 2020, an annual medical conference held virtually this week because of the coronavirus pandemic.

But outside experts greeted the report with skepticism.

The absence of antibodies to H.I.V. is the most interesting thing about the case, said Dr. Steve Deeks, an H.I.V. researcher at the University of California, San Francisco, who was not involved in the work.

“There will be a lot of buzz, a lot of controversy about this part — everyone’s going to be skeptical,” he said. “Am I skeptical? Of course. Am I intrigued? Absolutely.”

It is too soon to say whether the Brazilian patient is truly virus-free, Dr. Deeks said, until independent labs have confirmed the test results. Even if they do, he added, it is unclear whether the man’s status is the result of the treatment combination he has received.

One in 20 people who start traditional antiretroviral treatment soon after they are infected also suppress the virus to undetectable levels.

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The patient was diagnosed with H.I.V. in October 2012, and started taking antiretroviral drugs two months later. In 2016, he was one of five people to join a clinical trial in which, in addition to standard cocktail therapy, they received three antiretroviral drugs for 48 weeks.

Two of the drugs, maraviroc and nicotinamide, are thought to lure H.I.V. out of its hiding spots in the body, allowing the other drugs to kill the virus. H.I.V. lurks in many so-called reservoirs, and previous studies have suggested that any strategy to rid the body of the virus must include a way to flush it out. Nicotinamide may also boost the immune system, said Dr. Ricardo Diaz, a member of the research team.

The patient returned to standard antiretroviral therapy after the trial ended. He stopped taking all antiretroviral drugs in March 2019. His blood has been tested every three weeks since then, and has shown no signs of the infection, according to the researchers.

“These are exciting findings, but they’re very preliminary,” said Dr. Monica Gandhi, an H.I.V. expert at U.C.S.F. and one of the conference organizers.

Nicotinamide has been used in many other studies without these results, she noted. And no drug “has worked so far in terms of long-term remission,” she said. “I’m not even sure this has worked. It’s one patient, so I think we can’t say we can achieve remission this way.”

The scientists in Brazil have offered to send samples for confirmatory tests to other labs. The researchers should repeat the negative antibody tests, and they plan to do so, Dr. Deeks said.

The researchers also must test the patient’s blood for antiretroviral drugs, he added: “The data raises the possibility that the participant continued his antiretroviral drugs without informing the study team. This would not be unprecedented.”

People in Brazil receive antiretroviral drugs through the public health system, and the transaction is registered, Dr. Diaz said at a press briefing on Tuesday.

“We don’t have a black market, because we don’t need this,” he said. “And there was no registry that this patient got any drugs from the public system.”

Still, he said, the team will check the patient’s blood for antiviral drug use that the researchers did not know about.

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Lupus patient

Lupus patient on hydroxychloroquine contracts coronavirus, report says – Fox News

A Wisconsin woman who for 19 years has been taking hydroxychloroquine — the same drug President Trump announced he has been taking in order to preventatively ward off the novel coronavirus – claims she has contracted COVID-19. The woman, whose last name was not revealed by WISN.com, said she was prescribed the anti-malarial drug for lupus.

In mid-April, she developed several telltale signs of the virus and eventually tested positive at Aurora Medical Center, according to WISN.com.

TRUMP’S CLAIM HE TAKES HYDROXYCHLOROQUINE PROMPTS WARNINGS FROM HEALTH EXPERTS

“When they gave the diagnosis, I felt like it was a death sentence. I was like, ‘I’m going to die,’” she told the news outlet. “I’m like, ‘How can I be sick? How I’m on the hydroxychloroquine.’ They were like, ‘Well, nobody ever said that was the cure or that was going to keep you safe,’ and it definitely did not.”

Kim told the news outlet that she was in the hospital for seven days where she received oxygen and plasma before she was released to go home.

Trump’s announcement on Monday that he had been taking hydroxychloroquine and a zinc supplement daily after requesting it from his doctor for the last two weeks sparked a fury of debate among experts and health officials who voiced concern about the safety of the drug.

Dr. Sean Conley, the president’s physician, said that he and Trump discussed the drug at length and decided that the potential benefits outweighed the risks.

HYDROXYCHLOROQUINE USE SHOULD BE AVOIDED OUTSIDE HOSPITALS, FDA WARNS

However, Dr. Janette Nesheiwat, a Fox News medical contributor, warned that may not be the case for everyone.

“You have to have a discussion with your doctor to decide if it is best for you,” she said. “It is not going to be good for everyone but it may be beneficial and potentially life-saving for others.”

The Food and Drug Administration (FDA) has previously warned against the use of the drug outside of hospital settings after reports of “serious heart rhythm problems.”

“The FDA is aware of reports of serious heart rhythm problems in patients with COVID-19 treated with hydroxychloroquine or chloroquine, often in combination with azithromycin,” the agency said. “We are also aware of increased use of these medicines through outpatient prescriptions. Therefore, we would like to remind health care professionals and patients of the known risks associated with both hydroxychloroquine and chloroquine.”

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In addition to lupus, the medication has also been prescribed to treat rheumatoid arthritis. However, in two recent large observational studies, patients were not found to benefit from the drug. Two additional studies published in the medical journal BMJ reached the same conclusion.

Fox News’ Madeline Farber and Bradford Betz contributed to this report.

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